' 
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
6.9
USERS' SCORE
Very Good
Based on 3 Reviews
8.2
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
7
Vitamin D's role in heart health
The Impact of Vitamin D Deficiency on Coronary Artery Disease Severity Based on Myocardial Perfusion Imaging: A Cross-Sectional Study.
Direct focus on heart disease
We examined how low levels of vitamin D (Vit D) could impact the severity of heart disease, specifically looking at myocardial ischemia. Our study involved two hundred patients who underwent myocardial perfusion imaging at Namazi Hospital in Shiraz, Iran, in 2019. We assessed both the severity of ischemia in patients and their vitamin D levels.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
Read More
8
Vitamin D's impact on heart hypertrophy
Contributing role and molecular basis of Vitamin D/Vitamin D receptor deficiency in hyperhomocysteinemia-induced cardiac hypertrophy.
Significant relevance in heart disease
We explored the relationship between vitamin D deficiency and heart disease, particularly how it interacts with a condition called hyperhomocysteinemia, which is known to promote heart issues. In our study, we examined both animal models (rats fed a diet to induce hyperhomocysteinemia) and heart cells under lab conditions to understand this interaction better.
Our findings revealed that hyperhomocysteinemia significantly lowered levels of vitamin D, specifically 1,25(OH)D, in the blood and heart tissues. We also noted an increase in the expression of an enzyme (CYP24A1) that breaks down vitamin D, indicating a disruption in its availability. Moreover, the presence of elevated homocysteine was linked to a decrease in vitamin D receptor (VDR) expression in heart tissues, complicating the heart's ability to respond to vitamin D’s effects.
By manipulating levels of VDR, we demonstrated that reducing VDR led to more heart cell growth, which is a sign of heart hypertrophy. Conversely, when VDR was overexpressed, we observed a decrease in hypertrophy, showing that vitamin D plays a protective role against heart enlargement during hyperhomocysteinemia. Additionally, a specific microRNA (miR-125b-5p) was found to repress VDR and contribute to heart cell growth, highlighting the complex regulatory network involved.
Our study concluded that vitamin D deficiency and reduced VDR contribute to heart issues associated with high levels of homocysteine by activating harmful cellular pathways. This underscores the potential significance of monitoring and supporting vitamin D levels, especially in individuals suffering from hyperhomocysteinemia.
Our findings revealed that hyperhomocysteinemia significantly lowered levels of vitamin D, specifically 1,25(OH)D, in the blood and heart tissues. We also noted an increase in the expression of an enzyme (CYP24A1) that breaks down vitamin D, indicating a disruption in its availability. Moreover, the presence of elevated homocysteine was linked to a decrease in vitamin D receptor (VDR) expression in heart tissues, complicating the heart's ability to respond to vitamin D’s effects.
By manipulating levels of VDR, we demonstrated that reducing VDR led to more heart cell growth, which is a sign of heart hypertrophy. Conversely, when VDR was overexpressed, we observed a decrease in hypertrophy, showing that vitamin D plays a protective role against heart enlargement during hyperhomocysteinemia. Additionally, a specific microRNA (miR-125b-5p) was found to repress VDR and contribute to heart cell growth, highlighting the complex regulatory network involved.
Our study concluded that vitamin D deficiency and reduced VDR contribute to heart issues associated with high levels of homocysteine by activating harmful cellular pathways. This underscores the potential significance of monitoring and supporting vitamin D levels, especially in individuals suffering from hyperhomocysteinemia.
Read More
7
Vitamin D's impact on heart health
Low vitamin D levels are associated with impaired diastolic function in patients with acute coronary syndrome.
Significant association found
We set out to understand how vitamin D levels relate to diastolic function in patients experiencing acute coronary syndrome (ACS). Our study included 117 patients who were monitored before their discharge from the hospital. We used echocardiography to assess their heart function, specifically looking at how well their hearts could relax after beating—a key indicator of heart health.
The results revealed that those with low vitamin D levels tended to have more significant diastolic dysfunction. For instance, measures like the isovolumetric relaxation time (IVRT) and the E/e' ratio were notably higher in patients with lower vitamin D. Further analysis showed that vitamin D levels could predict the likelihood of developing diastolic dysfunction, making it an independent risk factor.
Overall, our findings suggest that vitamin D deficiency may contribute negatively to heart function in individuals with ACS. Highlighting the importance of maintaining adequate vitamin D levels, this research could encourage further exploration of vitamin D as a potential target for improving heart health in at-risk populations.
The results revealed that those with low vitamin D levels tended to have more significant diastolic dysfunction. For instance, measures like the isovolumetric relaxation time (IVRT) and the E/e' ratio were notably higher in patients with lower vitamin D. Further analysis showed that vitamin D levels could predict the likelihood of developing diastolic dysfunction, making it an independent risk factor.
Overall, our findings suggest that vitamin D deficiency may contribute negatively to heart function in individuals with ACS. Highlighting the importance of maintaining adequate vitamin D levels, this research could encourage further exploration of vitamin D as a potential target for improving heart health in at-risk populations.
Read More
Most Useful Reviews
8.8
Strengthens against heart disease
Vitamin D3 is essential for improving levels in the body, strengthening bones, and reducing chronic disease risks, including heart disease. It also enhances the immune system and promotes dental health. I’ve experienced positive effects from it.
Read More
8
Beneficial for heart disease
Vitamin D is incredibly beneficial for overall health, particularly bones and the heart. Many publications highlight the dangers of deficiency. The manufacturer is commendable, and the dosage is preventative. I’ve experienced no unpleasant effects after taking it.
Read More
8
Necessary for heart disease
Vitamin D3 deficiency is linked to impaired bone development and heart disease, among other issues. I take 2000 IU daily or 5000 every other day. Friends of mine have successfully raised their levels, highlighting that vitamin D from reputable brands is effective, including this one.
Read More
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Medical Researches
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Possibly Effective
Based on 8 Researches
6.9
8
Vitamin D3 and SGLT2i synergy explored
Unveiling the benefits of Vitamin D3 with SGLT-2 inhibitors for hypertensive obese obstructive sleep apnea patients.
Combined treatment benefits assessed
We conducted a study to explore how vitamin D3, combined with SGLT2 inhibitors, could influence heart health in hypertensive obese patients suffering from obstructive sleep apnea (OSA). This combination therapy was assessed for its effects on various health parameters and the quality of life of the participants.
In our investigation, patients were randomly assigned to receive either Dapagliflozin, vitamin D3, a combination of both, or no treatment at all over 16 weeks. We closely looked at measurements such as weight, blood pressure, blood sugar levels, liver health, and heart function among others.
Our findings were promising, revealing beneficial effects of combining vitamin D3 with SGLT2 inhibitors. Participants who received this combination reported improvements in their cardio-metabolic health and overall quality of life, suggesting a potential new approach to managing heart disease in this specific group of patients.
It is important to note that while this study highlights the synergistic benefits of vitamin D3 and SGLT2 inhibitors, the isolated impact of vitamin D itself on heart disease remains somewhat unclear. This complexity underscores the need for further research to fully understand vitamin D's role in cardiovascular health.
In our investigation, patients were randomly assigned to receive either Dapagliflozin, vitamin D3, a combination of both, or no treatment at all over 16 weeks. We closely looked at measurements such as weight, blood pressure, blood sugar levels, liver health, and heart function among others.
Our findings were promising, revealing beneficial effects of combining vitamin D3 with SGLT2 inhibitors. Participants who received this combination reported improvements in their cardio-metabolic health and overall quality of life, suggesting a potential new approach to managing heart disease in this specific group of patients.
It is important to note that while this study highlights the synergistic benefits of vitamin D3 and SGLT2 inhibitors, the isolated impact of vitamin D itself on heart disease remains somewhat unclear. This complexity underscores the need for further research to fully understand vitamin D's role in cardiovascular health.
Read More
8
Vitamin D's impact on heart hypertrophy
Contributing role and molecular basis of Vitamin D/Vitamin D receptor deficiency in hyperhomocysteinemia-induced cardiac hypertrophy.
Significant relevance in heart disease
We explored the relationship between vitamin D deficiency and heart disease, particularly how it interacts with a condition called hyperhomocysteinemia, which is known to promote heart issues. In our study, we examined both animal models (rats fed a diet to induce hyperhomocysteinemia) and heart cells under lab conditions to understand this interaction better.
Our findings revealed that hyperhomocysteinemia significantly lowered levels of vitamin D, specifically 1,25(OH)D, in the blood and heart tissues. We also noted an increase in the expression of an enzyme (CYP24A1) that breaks down vitamin D, indicating a disruption in its availability. Moreover, the presence of elevated homocysteine was linked to a decrease in vitamin D receptor (VDR) expression in heart tissues, complicating the heart's ability to respond to vitamin D’s effects.
By manipulating levels of VDR, we demonstrated that reducing VDR led to more heart cell growth, which is a sign of heart hypertrophy. Conversely, when VDR was overexpressed, we observed a decrease in hypertrophy, showing that vitamin D plays a protective role against heart enlargement during hyperhomocysteinemia. Additionally, a specific microRNA (miR-125b-5p) was found to repress VDR and contribute to heart cell growth, highlighting the complex regulatory network involved.
Our study concluded that vitamin D deficiency and reduced VDR contribute to heart issues associated with high levels of homocysteine by activating harmful cellular pathways. This underscores the potential significance of monitoring and supporting vitamin D levels, especially in individuals suffering from hyperhomocysteinemia.
Our findings revealed that hyperhomocysteinemia significantly lowered levels of vitamin D, specifically 1,25(OH)D, in the blood and heart tissues. We also noted an increase in the expression of an enzyme (CYP24A1) that breaks down vitamin D, indicating a disruption in its availability. Moreover, the presence of elevated homocysteine was linked to a decrease in vitamin D receptor (VDR) expression in heart tissues, complicating the heart's ability to respond to vitamin D’s effects.
By manipulating levels of VDR, we demonstrated that reducing VDR led to more heart cell growth, which is a sign of heart hypertrophy. Conversely, when VDR was overexpressed, we observed a decrease in hypertrophy, showing that vitamin D plays a protective role against heart enlargement during hyperhomocysteinemia. Additionally, a specific microRNA (miR-125b-5p) was found to repress VDR and contribute to heart cell growth, highlighting the complex regulatory network involved.
Our study concluded that vitamin D deficiency and reduced VDR contribute to heart issues associated with high levels of homocysteine by activating harmful cellular pathways. This underscores the potential significance of monitoring and supporting vitamin D levels, especially in individuals suffering from hyperhomocysteinemia.
Read More
7
Vitamin D's role in heart health
The Impact of Vitamin D Deficiency on Coronary Artery Disease Severity Based on Myocardial Perfusion Imaging: A Cross-Sectional Study.
Direct focus on heart disease
We examined how low levels of vitamin D (Vit D) could impact the severity of heart disease, specifically looking at myocardial ischemia. Our study involved two hundred patients who underwent myocardial perfusion imaging at Namazi Hospital in Shiraz, Iran, in 2019. We assessed both the severity of ischemia in patients and their vitamin D levels.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
Read More
7
Vitamin D influences cardiac health
Sirtuin 1 mediates the pro-survival effects of vitamin D in angiotensin II-induced hypertrophy of H9c2 cardiomyoblasts.
Explores vitamin D in heart disease
We explored the connection between vitamin D and heart disease, focusing on its effects in a specific scenario: the response of H9c2 cardiomyoblasts to angiotensin II (Ang II), a substance often involved in heart issues. In our study, we exposed these heart cells to Ang II alone and in combination with vitamin D while also manipulating the activity of a protein called SIRT1.
Our findings showed that while vitamin D significantly reduced the hypertrophy caused by Ang II—meaning it helped to keep the cells from growing excessively—this effect didn’t rely on SIRT1. Interestingly, when SIRT1 was blocked, vitamin D lost its ability to protect the cells from decreased viability, indicating that SIRT1 is essential for vitamin D’s pro-survival benefits but not for its anti-hypertrophic effects.
This suggests that vitamin D has a complex role in heart health. While it can prevent excessive cell growth, it needs SIRT1 to boost cell survival. Therefore, strategies that enhance SIRT1 activity alongside vitamin D could offer a promising path to tackle issues like cardiac hypertrophy and heart failure.
Our findings showed that while vitamin D significantly reduced the hypertrophy caused by Ang II—meaning it helped to keep the cells from growing excessively—this effect didn’t rely on SIRT1. Interestingly, when SIRT1 was blocked, vitamin D lost its ability to protect the cells from decreased viability, indicating that SIRT1 is essential for vitamin D’s pro-survival benefits but not for its anti-hypertrophic effects.
This suggests that vitamin D has a complex role in heart health. While it can prevent excessive cell growth, it needs SIRT1 to boost cell survival. Therefore, strategies that enhance SIRT1 activity alongside vitamin D could offer a promising path to tackle issues like cardiac hypertrophy and heart failure.
Read More
7
Vitamin D's impact on heart health
Low vitamin D levels are associated with impaired diastolic function in patients with acute coronary syndrome.
Significant association found
We set out to understand how vitamin D levels relate to diastolic function in patients experiencing acute coronary syndrome (ACS). Our study included 117 patients who were monitored before their discharge from the hospital. We used echocardiography to assess their heart function, specifically looking at how well their hearts could relax after beating—a key indicator of heart health.
The results revealed that those with low vitamin D levels tended to have more significant diastolic dysfunction. For instance, measures like the isovolumetric relaxation time (IVRT) and the E/e' ratio were notably higher in patients with lower vitamin D. Further analysis showed that vitamin D levels could predict the likelihood of developing diastolic dysfunction, making it an independent risk factor.
Overall, our findings suggest that vitamin D deficiency may contribute negatively to heart function in individuals with ACS. Highlighting the importance of maintaining adequate vitamin D levels, this research could encourage further exploration of vitamin D as a potential target for improving heart health in at-risk populations.
The results revealed that those with low vitamin D levels tended to have more significant diastolic dysfunction. For instance, measures like the isovolumetric relaxation time (IVRT) and the E/e' ratio were notably higher in patients with lower vitamin D. Further analysis showed that vitamin D levels could predict the likelihood of developing diastolic dysfunction, making it an independent risk factor.
Overall, our findings suggest that vitamin D deficiency may contribute negatively to heart function in individuals with ACS. Highlighting the importance of maintaining adequate vitamin D levels, this research could encourage further exploration of vitamin D as a potential target for improving heart health in at-risk populations.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 3 Reviews
8.2
8.8
Strengthens against heart disease
Vitamin D3 is essential for improving levels in the body, strengthening bones, and reducing chronic disease risks, including heart disease. It also enhances the immune system and promotes dental health. I’ve experienced positive effects from it.
8
Beneficial for heart disease
Vitamin D is incredibly beneficial for overall health, particularly bones and the heart. Many publications highlight the dangers of deficiency. The manufacturer is commendable, and the dosage is preventative. I’ve experienced no unpleasant effects after taking it.
8
Necessary for heart disease
Vitamin D3 deficiency is linked to impaired bone development and heart disease, among other issues. I take 2000 IU daily or 5000 every other day. Friends of mine have successfully raised their levels, highlighting that vitamin D from reputable brands is effective, including this one.
